Early age at menopause is associated with increased risk of dementia and mortality in women with Down syndrome.
J Alzheimers Dis
; 19(2): 545-50, 2010.
Article
en En
| MEDLINE
| ID: mdl-20110600
ABSTRACT
In a prospective longitudinal cohort study of dementia and mortality in persons with Down syndrome aged 45 years and older, 85 postmenopausal women were followed for a mean follow-up time of 4.3 years (range 0.0 to 7.4 years). The effect of age at menopause on age at diagnosis of dementia and survival was estimated using correlation analysis and Cox Proportional Hazard Model. We found a significant correlation between age at menopause and age at diagnosis of dementia (rho=0.52; p< 0.001), and between age at menopause and age at death (rho=0.49; p=0.01). Early age at menopause is associated with a 1.8 fold increased risk of dementia Hazard Ratio (HR) 1.82 (95%Confidence Interval (CI) 1.31-2.52) and with risk of death HR 2.05 (95%CI 1.33-3.16). Our study suggests that age at menopause in women with Down syndrome is a determinant of age at onset of dementia and mortality.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Menopausia
/
Síndrome de Down
/
Demencia
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Países Bajos