Birth-related factors and doctor-diagnosed wheezing and allergic sensitization in early childhood.
Allergy
; 65(9): 1116-25, 2010 Sep.
Article
en En
| MEDLINE
| ID: mdl-20121761
ABSTRACT
BACKGROUND:
To investigate the associations between clinical obstetric factors during birth and doctor-diagnosed wheezing and allergic sensitization during early childhood.METHODS:
We followed 410 Finnish women from late pregnancy until 18 months age of their children. All children were delivered at term. Doctor-diagnosed wheezing among children was established by questionnaires, while specific immunoglobulin E antibodies to inhalant and food allergens were measured in 388 children at 1 year of age. Data on maternal obstetric variables were recorded at the time of delivery.RESULTS:
Children of mothers with longer duration of ruptured fetal membranes before birth had significantly higher risk of doctor-diagnosed wheezing during early childhood compared to those children with shorter period of ruptured fetal membranes (III vs I quartile; aOR 6.65, 95% CI 1.99-22.18; P < 0.002 and IV vs I quartile; aOR 3.88, 95% CI 1.05-14.36, P < 0.043). Children who were born by Cesarean delivery had significantly less allergic sensitization at the age of 1 year compared to those who were born by vaginal route (16.0%vs 32.2%; aOR 0.34, 95% CI 0.14-0.80; P < 0.013). Furthermore, allergic sensitization tended to be more common in children with longer duration of labor before birth. No other birth-related obstetric factors, such as induction, the type of fetal membrane rupture during birth or quality of amniotic fluid were associated significantly with the examined outcomes.CONCLUSION:
The longer duration of the ruptured fetal membranes possibly reflected the higher risk of intrapartum infection at birth, and further increased the risk of doctor-diagnosed wheezing among offspring.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Rotura Prematura de Membranas Fetales
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Ruidos Respiratorios
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Parto Obstétrico
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Hipersensibilidad Inmediata
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Infant
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Male
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Newborn
/
Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
Allergy
Año:
2010
Tipo del documento:
Article
País de afiliación:
Finlandia