fMRI tracks reductions in repetitive behaviors in autism: two case studies.
Neurocase
; 16(4): 307-16, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20178033
ABSTRACT
Autism is characterized by abnormal prefrontal brain activation during cognitive control, a potential biomarker of repetitive behaviors. In this proof-of-principle study, functional magnetic resonance imaging (fMRI) was used to examine brain activity during an oddball task in two high-functioning males with autism before and after 12 weeks of treatment with citalopram, a selective serotonin reuptake inhibitor. One participant showed marked reductions in repetitive behaviors whereas the other showed mild worsening. Brain activation in relevant prefrontal regions increased in only the participant whose repetitive behavior symptoms improved. These findings suggest that fMRI may elucidate potential mechanisms of action of targeted autism interventions.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastorno Autístico
/
Conducta
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Imagen por Resonancia Magnética
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Neurocase
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
/
PSICOLOGIA
/
PSIQUIATRIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos