Rapid determination of lithium in serum samples by capillary electrophoresis.
Anal Bioanal Chem
; 396(7): 2543-6, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20179911
ABSTRACT
Lithium salts are still one of the most popular therapeutic approaches to the treatment of bipolar disorders, notwithstanding the introduction of more modern, less toxic drugs. Because of a narrow therapeutic range, lithium serum concentrations must be strictly monitored during the treatment to avoid life-threatening neurotoxicity. For this purpose, methods based on flame photometry or ion-selective electrodes are usually applied. The aim of the present work was to develop and validate a simple method for the determination of lithium in serum based on capillary zone electrophoresis with indirect detection. A validation of the method was carried out, including a comparison with an automated routine method based on ion-selective electrodes.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Análisis Químico de la Sangre
/
Monitoreo de Drogas
/
Compuestos de Litio
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Electroforesis Capilar
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Humans
Idioma:
En
Revista:
Anal Bioanal Chem
Año:
2010
Tipo del documento:
Article
País de afiliación:
Italia