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A pause in nucleus accumbens neuron firing is required to initiate and maintain feeding.
Krause, Michael; German, P Walter; Taha, Sharif A; Fields, Howard L.
Afiliación
  • Krause M; Ernest Gallo Clinic and Research Center, Wheeler Center for the Neurobiology of Addiction, and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA.
J Neurosci ; 30(13): 4746-56, 2010 Mar 31.
Article en En | MEDLINE | ID: mdl-20357125
Nucleus accumbens (NAc) inactivation increases food intake, indicating that NAc neurons exert ongoing inhibition of feeding. We previously described a subpopulation of NAc neurons that pause during sucrose licking and proposed that the pause permits consumption. We tested this hypothesis by first recording NAc neurons during sucrose consumption, and then electrically stimulating through the same electrodes. A large proportion of NAc shell and core neurons were inhibited during sucrose consumption, and local electrical stimulation abruptly interrupted licking. Effective stimulation sites were more anterior than ineffective sites in NAc. At low stimulus intensities, licking resumed immediately on stimulation offset. The latency to lick resumption from NAc neuron inhibition onset ( approximately 460 ms) was very similar to that after electrical stimulation offset ( approximately 440 ms). These results directly support the hypothesis that a significant subpopulation of NAc neurons inhibit palatable food consumption and that a pause in their firing is required to initiate and maintain consumption.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Conducta Alimentaria / Neuronas / Núcleo Accumbens Límite: Animals Idioma: En Revista: J Neurosci Año: 2010 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Conducta Alimentaria / Neuronas / Núcleo Accumbens Límite: Animals Idioma: En Revista: J Neurosci Año: 2010 Tipo del documento: Article País de afiliación: Estados Unidos