Bisamidines of 2,6-diaminoanthraquinone as antiamebic agents.

Fabio, P F; Fields, T L; Lin, Y; Burden, E J; Carvajal, S; Murdock, K C; Lang, S A

Fabio, P F; Fields, T L; Lin, Y; Burden, E J; Carvajal, S; Murdock, K C; Lang, S A.

J Med Chem ; 21(3): 273-6, 1978 Mar.

Article en En | MEDLINE | ID: mdl-203694

ABSTRACT

ABSTRACT

A series of bisamidines of 2,6-diaminoanthraquinone was synthesized and tested against cecal and hepatic forms of Entamoeba histolytica infections in rats and hamsters, respectively. A number of compounds were found to have good activity against infections in both species.

Asunto(s)

Amebiasis/tratamiento farmacológico; Antraquinonas/uso terapéutico; Entamebiasis/tratamiento farmacológico; Amebicidas/síntesis química; Amidinas/síntesis química; Amidinas/uso terapéutico; Animales; Antraquinonas/síntesis química; Cricetinae; Disentería Amebiana/tratamiento farmacológico; Entamoeba histolytica; Femenino; Absceso Hepático Amebiano/tratamiento farmacológico; Ratas

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antraquinonas / Entamebiasis / Amebiasis Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 1978 Tipo del documento: Article

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