Salivary gland regeneration.
Front Oral Biol
; 14: 107-128, 2010.
Article
en En
| MEDLINE
| ID: mdl-20428014
ABSTRACT
The ability of animal salivary glands to recover from an experimentally-induced atrophic state offers hope that human salivary glands may be regenerated following injury. Examination of the mechanisms of regeneration in animal models has revealed processes which resemble the embryonic formation of salivary glands. Secretory proteins present in regenerated acinar and ductal cells are the same as found in the perinatal salivary glands. The use of microarrays to reveal global gene changes has, in combination with bioinformatic techniques, identified some of the important signalling cascades operating in the early stages of glandular regeneration. The role of stem cells is also considered and would fit in with current ideas of glandular regeneration, however the isolation and subsequent differentiation of stem cells into a normal reflexly secreting gland still requires considerable research.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regeneración
/
Glándulas Salivales
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Front Oral Biol
Asunto de la revista:
ODONTOLOGIA
Año:
2010
Tipo del documento:
Article