Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists.
Bioorg Med Chem Lett
; 20(12): 3573-8, 2010 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-20493696
ABSTRACT
The membrane bound large-conductance, calcium-activated potassium channel (BKCa) is an important regulator of neuronal activity. Here we describe the identification and structure-activity relationship of a novel class of potent tetrahydroquinoline BKCa agonists. An example from this class of BKCa agonists was shown to depress the spontaneous neuronal discharges in an electrophysiological model of migraine.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Subunidades alfa de los Canales de Potasio de Gran Conductancia Activados por Calcio
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos