Depolarization-induced release of ATP from cholinergic synaptosomes is not blocked by botulinum toxin type A.
Neurochem Int
; 10(3): 295-302, 1987.
Article
en En
| MEDLINE
| ID: mdl-20501099
ABSTRACT
We report here the effects of Botulinum Toxin type A on the release of ATP and Acetylcholine from Torpedo electric organ synaptosomes. Our results show that Botulinum Toxin type A inhibits specifically the K(+)-induced release of Acetylcholine from synaptosomes without affecting the release of ATP. Membrane potential and calcium uptake into cholinergic nerve terminals are not modified after Botulinum Toxin poisoning. It is suggested that either most of the ATP released during the depolarization of the cholinergic synaptosomes does not originate from cholinergic synaptic vesicles or that there are two populations of synaptic vesicles, Acetylcholine-enriched synaptic vesicles and ATP-enriched synaptic vesicles. However, the possibility that the ACh and ATP released could come from different intrasynaptosomal compartments cannot be excluded.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Neurochem Int
Año:
1987
Tipo del documento:
Article
País de afiliación:
España