Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES III.
Cancer Causes Control
; 21(10): 1575-83, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-20512526
ABSTRACT
PURPOSE:
Low cholesterol levels and statin drugs may protect against prostate cancer with a worse prognosis. Their protective mechanism is unknown, but has been hypothesized to be related to cholesterol's role as a sex steroid hormone precursor. We evaluated whether serum testosterone and estradiol differ by cholesterol or cholesterol-lowering drug use. MATERIALS ANDMETHODS:
Testosterone and estradiol were measured for 1,457 male participants in the Third National Health and Nutrition Examination Survey. We estimated multivariable-adjusted geometric mean hormone concentration by quintiles of cholesterol concentration and by cholesterol-lowering drugs use.RESULTS:
Across quintiles of cholesterol, testosterone level did not differ (mean, 95% confidence interval (CI); Q1 5.25, 5.02-5.49, Q5 5.05, 4.76-5.37 ng/ml; p-trend = 0.32), whereas estradiol levels were lower (Q1 38.7, 36.9-40.5; Q5 33.1, 31.8-34.5 pg/ml; p-trend < 0.0001). Neither testosterone (no 5.12, 4.94-5.30, yes 4.91, 4.33-5.57 ng/ml, p = 0.57) nor estradiol (no 35.9, 34.8-37.1; yes 33.9, 29.4-39.2 pg/ml; p = 0.39) differed by cholesterol-lowering drugs use.CONCLUSION:
Testosterone did not differ by cholesterol or cholesterol-lowering drug use. Estradiol was lower in men with higher cholesterol, but did not differ by cholesterol-lowering drug use. Our results suggest that the lower risk of advanced prostate cancer among statin users is not readily explained by a cholesterol-mediated effect of statins on sex hormone levels.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Testosterona
/
Colesterol
/
Estradiol
/
Anticolesterolemiantes
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Causes Control
Asunto de la revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos