Carcinogenicity and acute toxicity of dimethylnitrosamine in rainbow trout (Salmo gairdneri).
J Natl Cancer Inst
; 60(5): 1127-31, 1978 May.
Article
en En
| MEDLINE
| ID: mdl-205662
ABSTRACT
Four-week-old rainbow trout (Salmo gairdneri) were fed diets containing 0, 3, 50, 200, 400, and 800 ppm dimethylnitrosamine (DMN) for 52 weeks. At the end of 52 weeks, the fish were fed a control diet without DMN for an additional 26 weeks. Samples were taken at 26, 52, and 78 weeks to determine tumor incidence. A dose-related carcinogenic response was established from these results, and an equation was derived to relate the level of the carcinogen to the hepatocellular carcinoma incidence. From a published dose-response study that used outbred Porton rats, a second equation was derived for comparison. Rats and trout were approximately equal in their sensitivity to DMN carcinogenesis. The median lethal dose after ip injection of DMN was 1,770 mg/kg body weight in rainbow trout. Relative to the range of 15-50 mg/kg body weight reported for several mammalian species, trout were resistant to the acute toxicity of DMN.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinógenos
/
Carcinoma Hepatocelular
/
Dimetilnitrosamina
/
Neoplasias Hepáticas
/
Nitrosaminas
Límite:
Animals
Idioma:
En
Revista:
J Natl Cancer Inst
Año:
1978
Tipo del documento:
Article