Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administration.
Ther Drug Monit
; 32(4): 497-503, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20592651
ABSTRACT
Sweat patches (n = 350) were collected throughout gestation from 29 opioid-dependent pregnant women participating in an outpatient methadone-assisted therapy program. Volunteers provided informed consent to participate in institutional review board-approved protocols. Methadone was eluted from sweat patches with sodium acetate buffer, followed by solid-phase extraction and quantification by gas chromatography mass spectrometry (limit of quantification > or = 10 ng/patch). Methadone was present in all weekly patches (n = 311) in concentrations ranging from 10.2 to 12,129.7 nanograms per patch and in 92.3% of short-term patches (n = 39, worn for 12 or 24 hours) in concentrations up to 3303.9 nanograms per patch. Correlation between patch concentrations and total amount of drug administered (r = 0.224), and concentrations and duration of patch wear (r = 0.129) were both weak. Although there were large intra- and intersubject variations in sweat drug concentrations, sweat testing was an effective alternative technique to qualitatively monitor illicit drug use and simultaneously document methadone medication-assisted treatment.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sudor
/
Embarazo
/
Analgésicos Opioides
/
Metadona
Tipo de estudio:
Guideline
Límite:
Adult
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Female
/
Humans
Idioma:
En
Revista:
Ther Drug Monit
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos