The polypeptide core of Microcin E492 stably associates with the mannose permease and interferes with mannose metabolism.
Res Microbiol
; 161(8): 706-10, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-20674740
ABSTRACT
Microcin E492 (MccE492) is an antibacterial protein whose activity on target cells requires ManYZ, the inner membrane component of the mannose permease. We show here that MceA, the polypeptide core of MccE492, stably associates with ManYZ both in the presence and in the absence of MceB, the MccE492 immunity protein. The two known physiological activities of the mannose permease were assayed in cells co-expressing MceA and MceB. Under these conditions, growth on mannose as the sole carbon source is prevented; this was not observed in cells expressing only MceB. In contrast, susceptibility to bacteriophage λ infection was not affected.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bacteriocinas
/
Sistema de Fosfotransferasa de Azúcar del Fosfoenolpiruvato
/
Klebsiella pneumoniae
/
Manosa
/
Antibacterianos
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Res Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Suiza