Identification of 2,3,6-trisubstituted quinoxaline derivatives as a Wnt2/ß-catenin pathway inhibitor in non-small-cell lung cancer cell lines.
Bioorg Med Chem Lett
; 20(19): 5900-4, 2010 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-20729080
ABSTRACT
We screened 1434 small heterocyclic molecules and identified thirteen 2,3,6-trisubstituted quinoxaline derivatives that were able to inhibit the Wnt/ß-catenin signal pathway and cell proliferation. In the screen, some of the hit compounds such as the ethylene group-coupled quinoxaline derivatives were shown to hold promise for use as potential small-molecule inhibitors of the Wnt/ß-catenin signal pathway in non-small-cell lung cancer cell lines.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinoxalinas
/
Transducción de Señal
/
Carcinoma de Pulmón de Células no Pequeñas
/
Proteínas Wnt
/
Beta Catenina
/
Neoplasias Pulmonares
/
Antineoplásicos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article