The use of cell-delivered gene therapy for the treatment of HIV/AIDS.
Immunol Res
; 48(1-3): 84-98, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-20737298
ABSTRACT
HIV/AIDS is a disease that impairs immune function, primarily by decreasing T-lymphocyte count. Its progression can be contained by highly active antiretroviral therapy (HAART), but there are side effects that can be severe, and the development of resistance often forces the physician to modify the HAART regimen. There are no vaccines available for HIV. An alternative approach that could provide a path to a curative therapy is the use of cell-delivered gene therapy in which an anti-HIV gene(s) is introduced into hematopoietic cells to produce a population that is protected from the effects of HIV. In this paper, we review the field and discuss an approach using a short hairpin RNA to CCR5, an important co-receptor for HIV.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Hematopoyéticas
/
Infecciones por VIH
/
Receptores del VIH
/
VIH
/
Trasplante de Células Madre Hematopoyéticas
/
Receptores CCR5
/
ARN Interferente Pequeño
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos