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Gene signatures in hepatocellular carcinoma (HCC).
Andrisani, Ourania M; Studach, Leo; Merle, Philippe.
Afiliación
  • Andrisani OM; Basic Medical Sciences Department and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States. andrisao@purdue.edu
Semin Cancer Biol ; 21(1): 4-9, 2011 Feb.
Article en En | MEDLINE | ID: mdl-20851183
Primary hepatocellular carcinoma (HCC) is a significant human cancer globally, with poor prognosis. New and efficacious therapy strategies are needed as well as new biomarkers for early detection of at-risk patients. In this review, we discuss select microarray studies of human HCCs, and propose a gene signature that has promise for clinical/translational application. This gene signature combines the proliferation cluster of genes and the hepatic cancer initiating/stem cell gene cluster for identification of HCCs with poor prognosis. Evidence from cell-based assays identifies the existence of a mechanistic link between these two gene clusters, involving the proliferation cluster gene polo-like kinase 1 (PLK1). We propose that PLK1 is a promising therapy target for HCC.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Semin Cancer Biol Asunto de la revista: NEOPLASIAS Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Semin Cancer Biol Asunto de la revista: NEOPLASIAS Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos