Decreased bone turnover in children and adolescents with well controlled type 1 diabetes.
J Pediatr Endocrinol Metab
; 23(7): 697-707, 2010 Jul.
Article
en En
| MEDLINE
| ID: mdl-20857842
ABSTRACT
AIM:
Osteoporosis is a common long-term complication of type 1 diabetes (T1DM). We aimed to determine whether bone mineral density (BMD) and turnover are already altered during childhood. PATIENTS ANDMETHODS:
We recruited 27 T1DM children and 32 controls (age 10.5 +/- 2.5 yr.) and measured BMD (dual-energy x-ray absorptiometry); bone biomarkers levels (osteocalcin OC; procollagen type 1 propeptides amino-terminal PINP; crosslinking telopeptides of type 1 collagen C-terminal CTX), glycated hemoglobin (HbA1c), dietary intake and physical activity.RESULTS:
Patients with T1DM had lower levels of OC (70.3 +/- 3.3 vs 105.3 +/- 6.8), PINP (556.4 +/- 47.6 vs 716.3 +/- 53.8), CTX(0.97 +/- 0.07 vs 1.20 +/- 0.08), physical activity, and calcium intake. Biomarkers were negatively correlated with HbA1c. Though, BMD was similar among groups and not related to HbA1c, disease duration, physical activity or dietary intakes.CONCLUSIONS:
Bone turnover is altered in T1DM children, whereas BMD remains normal during growth. Physical activity and optimal calcium intakes may improve bone metabolism and delay osteoporosis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Remodelación Ósea
/
Diabetes Mellitus Tipo 1
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Suiza