New anticoagulants for the prevention of thromboembolism.
Curr Pharm Des
; 16(31): 3472-4, 2010.
Article
en En
| MEDLINE
| ID: mdl-20858184
ABSTRACT
The traditional agents used for thromboprophylaxis are effective and safe but have limitations particularly related to ease of administration. Newer agents targeting single coagulation factors such as the direct thrombin inhibitor dabigatran and the factor Xa inhibitors rivaroxaban and apixaban have demonstrated efficacy and safety for thromboembolism prophylaxis in the orthopedic population and have the additional benefit of oral administration and predictable pharmacokinetics. Pharmacology of the new anticoagulants and published data on the use of these agents in total knee and hip replacement patients will be reviewed in this article.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Posoperatorias
/
Pirazoles
/
Piridinas
/
Piridonas
/
Tiofenos
/
Bencimidazoles
/
Morfolinas
/
Tromboembolia Venosa
/
Anticoagulantes
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Curr Pharm Des
Asunto de la revista:
FARMACIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Canadá