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Pulsed magnetic field induces angiogenesis and improves cardiac function of surgically induced infarcted myocardium in Sprague-Dawley rats.
Yuan, Yuan; Wei, Liping; Li, Fei; Guo, Wenyi; Li, Weijie; Luan, Ronghua; Lv, Anlin; Wang, Haichang.
Afiliación
  • Yuan Y; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Cardiology ; 117(1): 57-63, 2010.
Article en En | MEDLINE | ID: mdl-20924179
ABSTRACT

OBJECTIVE:

It was the aim of this study to investigate the impact of pulsed magnetic field (PMF) on ischemic myocardium, though it has been reported that PMF treatment is a safe and effective method to facilitate bone and cutaneous wound healing.

METHODS:

In this report, we describe a study in which 10 Hz 4 mT PMF and 15 Hz 6 mT PMF was used to treat rats with myocardial infarction (MI).

RESULTS:

After 28 days of treatment, the rats treated with 15 Hz 6 mT PMF exhibited decreased left ventricular end-diastolic pressure and accelerated maximum dp/dt of left ventricular pressure when compared with the untreated MI and the MI + 10 Hz 4 mT groups. Additionally, capillary density was increased and infarction area size was decreased in the MI + 15 Hz 6 mT group. Furthermore, the plasma vascular endothelial growth factor concentration and the protein expression of vascular endothelial growth factor receptor 2 in myocardial tissue were increased in rats of the MI + 15 Hz 6 mT group.

CONCLUSION:

This study shows that 15 Hz 6 mT PMF promotes myocardial angiogenesis and improves cardiac function after MI in rats. This suggests that there is a potential use for some PMF signal strengths in ischemic myocardial disease.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Función Ventricular Izquierda / Neovascularización Fisiológica / Magnetoterapia / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cardiology Año: 2010 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Función Ventricular Izquierda / Neovascularización Fisiológica / Magnetoterapia / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cardiology Año: 2010 Tipo del documento: Article País de afiliación: China