Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst.
J Am Chem Soc
; 132(44): 15499-501, 2010 Nov 10.
Article
en En
| MEDLINE
| ID: mdl-20961047
ABSTRACT
A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Ribosomas
Idioma:
En
Revista:
J Am Chem Soc
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos