[Advancement of methanol poisoning mechanism research].
Fa Yi Xue Za Zhi
; 26(4): 294-6, 2010 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-20967961
ABSTRACT
The methanol poisoning by oral intake or skin contact occurs occasionally, which may have serious consequences including blindness and/or death. Methanol and its metabolites, formaldehyde and formic acid, are associated with metabolic acidosis, visual dysfunction and neurological symptoms. At present, the mechanism of methanol poisoning primarily focuses on the cell hypoxia, the alteration of structure and biological activity induced by free radical and lactic acid. Meanwhile, methanol poisoning causes changes in the balance between the production of free radicals and antioxidant capacity and in the proteases-protease inhibitors system, which lead to a series of disturbances.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Acidosis
/
Metanol
/
Formaldehído
/
Formiatos
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Fa Yi Xue Za Zhi
Asunto de la revista:
JURISPRUDENCIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
China