The paradox of dopamine and angiotensin II-mediated Na(+), K(+)-ATPase regulation in renal proximal tubules.
Clin Exp Hypertens
; 32(7): 464-8, 2010.
Article
en En
| MEDLINE
| ID: mdl-21029011
ABSTRACT
Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na(+) and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na(+), K(+)-ATPase (NKA). The antagonistic actions were mediated by the phosphorylation of different position of NKA α1-subunit and different Pals-associated tight junction protein (PATJ) PDZ domains, the different protein kinase C (PKC) isoforms (PKC-ß, PKC-ζ), the common adenylyl cyclase (AC) pathway, and the crosstalk and balance between DA and Ang II to NKA regulation. Besides, Ang II-mediated NKA modulation has bi-phasic effects.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Angiotensina II
/
Dopamina
/
ATPasa Intercambiadora de Sodio-Potasio
/
Túbulos Renales Proximales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Exp Hypertens
Año:
2010
Tipo del documento:
Article
País de afiliación:
China