Neuromuscular transmission is not impaired in axonal Guillain--Barré syndrome.
J Neurol Neurosurg Psychiatry
; 82(10): 1174-7, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21071752
ABSTRACT
BACKGROUND:
Previous studies have shown that anti-GQ1b antibodies induce massive neuromuscular blocking. If anti-GM1 and -GD1a antibodies have similar effects on the neuromuscular junction (NMJ) in human limb muscles, this may explain selective motor involvement in axonal Guillain--Barré syndrome (GBS).METHODS:
Axonal-stimulating single-fibre electromyography was performed in the extensor digitorum communis muscle of 23 patients with GBS, including 13 with the axonal form whose sera had a high titre of serum IgG anti-GM1 or -GD1a antibodies.RESULTS:
All patients with axonal or demyelinating GBS showed normal or near-normal jitter, and no blocking.CONCLUSION:
In both axonal and demyelinating GBS, neuromuscular transmission is not impaired. Our results failed to support the hypothesis that anti-GM1 or -GD1a antibody affects the NMJ. In GBS, impulse transmission is presumably impaired in the motor nerve terminal axons proximal to the NMJ.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Axones
/
Transmisión Sináptica
/
Síndrome de Guillain-Barré
/
Unión Neuromuscular
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón