Risk for antipsychotic-induced extrapyramidal symptoms: influence of family history and genetic susceptibility.
Psychopharmacology (Berl)
; 214(3): 729-36, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21072501
ABSTRACT
OBJECTIVES:
This study aims to further evaluate the impact of family history of primary movement disorders (FHpMD) and a candidate genetic variant on risk of antipsychotic-induced extrapyramidal symptoms (EPS).METHODS:
We examined 156 (76 men) inpatients receiving antipsychotics for EPS and FHpMD stratified by patient characteristics. The genetic analysis included genotyping of a multiallelic dinucleotide polymorphism in the ATP1A3 gene.RESULTS:
EPS lifetime prevalence was 69% and more frequent in the presence of FHpMD (p = 0.052), particularly in patients younger than 60 years (p = 0.012) and with acute dystonic reactions. The ATP1A3 polymorphism showed an allele length-dependent association with parkinsonism (p=0.019 uncorrected, p=0.057 corrected) exclusively. Carriers of the shortest allele had a 7.7-fold increased risk for parkinsonism.CONCLUSIONS:
The association of FHpMD and EPS may be linked to the EPS subtype and age of the patient. A common ATP1A3 genomic variation may represent a susceptibility factor for the risk for antipsychotic-induced parkinsonism in an allele-dependent manner.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antipsicóticos
/
Enfermedades de los Ganglios Basales
/
Salud de la Familia
/
ATPasa Intercambiadora de Sodio-Potasio
/
Predisposición Genética a la Enfermedad
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania