Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

Mo, SangJoon; Kim, Dong Hwan; Lee, Jong Hyun; Park, Je Won; Basnet, Devi B; Ban, Yeon Hee; Yoo, Young Ji; Chen, Shu-wei; Park, Sung Ryeol; Choi, Eun Ae; Kim, Eunji; Jin, Ying-Yu; Lee, Sung-Kwon; Park, Ju Yeol; Liu, Yuan; Lee, Mi Ok; Lee, Keum Soon; Kim, Sang Jun; Kim, Dooil; Park, Byoung Chul; Lee, Sang-gi; Kwon, Ho Jeong; Suh, Joo-Won; Moore, Bradley S; Lim, Si-Kyu; Yoon, Yeo Joon

Mo, SangJoon; Kim, Dong Hwan; Lee, Jong Hyun; Park, Je Won; Basnet, Devi B; Ban, Yeon Hee; Yoo, Young Ji; Chen, Shu-wei; Park, Sung Ryeol; Choi, Eun Ae; Kim, Eunji; Jin, Ying-Yu; Lee, Sung-Kwon; Park, Ju Yeol; Liu, Yuan; Lee, Mi Ok; Lee, Keum Soon; Kim, Sang Jun; Kim, Dooil; Park, Byoung Chul; Lee, Sang-gi; Kwon, Ho Jeong; Suh, Joo-Won; Moore, Bradley S; Lim, Si-Kyu; Yoon, Yeo Joon.

Afiliación

Mo S; Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.

J Am Chem Soc ; 133(4): 976-85, 2011 Feb 02.

Article en En | MEDLINE | ID: mdl-21175203

Asunto(s)

Malonil Coenzima A/biosíntesis; Malonil Coenzima A/química; Sintasas Poliquetidas/metabolismo; Eliminación de Secuencia; Tacrolimus/análogos & derivados; Tacrolimus/metabolismo; Malonil Coenzima A/metabolismo; Familia de Multigenes; Streptomyces/enzimología; Streptomyces/genética; Streptomyces/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tacrolimus / Eliminación de Secuencia / Sintasas Poliquetidas / Malonil Coenzima A Idioma: En Revista: J Am Chem Soc Año: 2011 Tipo del documento: Article

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