An atom-economical access to ß-heteroarylated ketones from propargylic alcohols via tandem ruthenium/indium catalysis.

ABSTRACT

The direct and chemoselective synthesis of ß-heteroarylated ketones from secondary propargyl alcohols through tandem Ru/In catalysis is reported. Both electron-rich and neutral heteroarenes, such as furans and indoles, efficiently undergo the redox isomerization/conjugate addition (RICA) sequence to provide the corresponding adducts in yields of up to 97%.