Daidzein/cyclodextrin/hydrophilic polymer ternary systems.
Drug Dev Ind Pharm
; 37(8): 886-93, 2011 Aug.
Article
en En
| MEDLINE
| ID: mdl-21247375
ABSTRACT
OBJECTIVE:
To evaluate the effect of different cyclodextrins (ß-cyclodextrin [ß-CD], methyl-ß-cyclodextrin [Mß-CD], or hydroxypropyl-ß-cyclodextrin [HPß-CD]) and/or hydrophilic polymers (carboxymethylcellulose, hydroxypropylmethylcellulose [HPMC], polyethyleneglycol, or polyvinylpyrrolidone [PVP]) on daidzein solubility in water. MATERIALS ANDMETHODS:
The corresponding associations were characterized in aqueous media using phase-solubility studies. The morphology of daidzein/cyclodextrin freeze-dried complexes was characterized using scanning electron microscopy, and their spatial configuration was proposed by means of nuclear magnetic resonance spectroscopy. RESULTS ANDDISCUSSION:
In the presence of 6 mM of cyclodextrins, the solubility of daidzein in water was significantly enhanced 5.7-fold (ß-CD), 7.2-fold (Mß-CD), and 9.4-fold (HPß-CD). The analysis of the three solid complexes proved that the formation of inclusion complexes occurred through the insertion of the B and C rings of daidzein molecule into the cyclodextrins cavity. The association of daidzein/cyclodextrin complexes to the hydrophilic polymers HPMC or PVP (1%, w/w) was able to improve the solubility of daidzein even further.CONCLUSION:
The highest solubilizing effect was obtained for daidzein/HPß-CD/PVP ternary system (12.7-fold).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polímeros
/
Ciclodextrinas
/
Fitoestrógenos
/
Isoflavonas
Idioma:
En
Revista:
Drug Dev Ind Pharm
Año:
2011
Tipo del documento:
Article
País de afiliación:
Brasil