Herbal medicines and infectious diseases: characterization by LC-SPE-NMR of some medicinal plant extracts used against malaria.
Planta Med
; 77(11): 1139-48, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21328178
ABSTRACT
The extracts of two medicinal plants used in traditionalmedicine against malariawere characterized by means of an LCSPENMR and LCMS platform. The structure of a series of major constituents from Bafodeya benna, as well as minor constituents from Ormocarpum kirkii, was determined. Bafodeya benna was found to contain (2R,3R)-taxifolin-3-O-α-L-rhamnoside or astilbin, and its isomers neoastilbin, neoisoastilbin, and isoastilbin, as well as quercetin-3-O-α-L-rhamnoside. From Ormocarpum kirkii, a series of known flavonoids and biflavonoids was obtained, as well as three new compounds, i.e., 7,7''-di-O-ß-D-glucosyl-(−)-chamaejasmin, 7-O-ß-D-glucosyl-(I-3,II-3)-biliquiritigenin, and isovitexin-(I-3,II-3)-naringenin. The isolated constituents may explain, at least in part, the traditional use against malaria. LCSPENMR, in combination with LCMS, is a powerful tool for the fast characterization of plant extracts, in order to define priorities at an early stage of a fractionation procedure. In addition, herbal medicinal products can completely be characterized, both with regard to their major as well as their minor constituents.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Extractos Vegetales
/
Espectroscopía de Resonancia Magnética
Idioma:
En
Revista:
Planta Med
Año:
2011
Tipo del documento:
Article
País de afiliación:
Bélgica