Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer.
Cancer Lett
; 304(2): 137-43, 2011 May 28.
Article
en En
| MEDLINE
| ID: mdl-21397389
ABSTRACT
In ovarian cancer, the molecular targeted chemotherapeutics could increase the efficiency of low-dose radiotherapy while decreasing injury to adjusted organs. In irradiated A2780 human ovarian carcinoma cells, cytosolic phospholipase A2 (cPLA(2)) inhibitor AACOCF(3) prevented activation of pro-survival Akt signaling and enhanced cell death. The potential molecular mechanisms of this effect could involve signaling through lysophosphatidic acid receptors. In the heterotopic A2780 tumor model using nude mice, cPLA(2) inhibition significantly delayed tumor growth compared to treatment with radiation or vehicle alone. These results identify cPLA(2) as a molecular target to enhance the therapeutic ratio of radiation in ovarian cancer.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Fármacos Sensibilizantes a Radiaciones
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Adenocarcinoma
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Ácidos Araquidónicos
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Fosfolipasas A2 Citosólicas
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Cancer Lett
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos