Paramutation: a process for acquiring trans-generational regulatory states.
Curr Opin Plant Biol
; 14(2): 210-6, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21420347
ABSTRACT
Basic tenets of Mendelian inheritance are violated by paramutations in which trans-homolog interactions lead to heritable changes in gene regulation and phenotype. First described in plants, similar behaviors have now been noted in diverse eukaryotes. Genetic and molecular studies of paramutations occurring in maize indicate that components of a small interfering RNA (siRNA) biogenesis pathway are required for the maintenance of meiotically heritable regulatory states. Although these findings lead to a hypothesis that siRNAs themselves mediate paramutation interactions, an assessment of existing data supports the opinion that siRNAs alone are insufficient. Recent evidence implies that transcription of paramutation-associated repeats and siRNA-facilitated chromatin changes at affected loci are involved in directing and maintaining the heritable changes in gene regulation that typify paramutations.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN de Planta
/
Regulación de la Expresión Génica de las Plantas
/
Zea mays
/
Mutación
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Curr Opin Plant Biol
Asunto de la revista:
BOTANICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos