Nanocrystallization of poorly water soluble drugs for parenteral administration.
J Biomed Nanotechnol
; 7(1): 127-9, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-21485836
ABSTRACT
Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug. Three different preparations of Amp B were produced by using three different surfactants Tween80, Pluronic F68, Soya Lecithin and assessed for their efficacy and stability. In this study the Amp B nanosuspension formulation, with the smaller particle size, can be effectively produced with the Nanoedge Method. The pharmacokinetic profiles of Amp B when given in the nanosuspension formulation were different compared to the corresponding raw drug.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Agua
/
Anfotericina B
/
Cristalización
/
Nanocápsulas
Límite:
Animals
Idioma:
En
Revista:
J Biomed Nanotechnol
Año:
2011
Tipo del documento:
Article
País de afiliación:
India