Effect of biologic agents on regulatory T cells.
Transplant Rev (Orlando)
; 25(3): 110-6, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21514136
ABSTRACT
The balance between effector T cells and regulatory T cells (Tregs) is central to transplant tolerance. Therefore, the impact of immunosuppressive therapies on their fate is a major determinant of long-term allograft outcome. The biologic agents are new molecules that show promise as more selective therapies with less adverse effects. Because they target mostly surface markers or costimulatory pathways of lymphocytes, it is of critical importance to evaluate their effect on both effector T cells and Tregs. The present review provides a brief summary of Tregs physiology and then discusses actual knowledge on the impact of the biologic agents on the frequency of Tregs as well as their function in vitro and in vivo in humans.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Linfocitos T Reguladores
/
Tolerancia al Trasplante
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Transplant Rev (Orlando)
Asunto de la revista:
TRANSPLANTE
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos