Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study.
Am J Respir Crit Care Med
; 184(4): 414-20, 2011 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-21562134
ABSTRACT
RATIONALE The characterization of young adults who develop late-onset diseases may augment the detection of novel genes and promote new pathogenic insights. METHODS:
We analyzed data from 2,500 individuals of African and European ancestry in the COPDGene Study. Subjects with severe, early-onset chronic obstructive pulmonary disease (COPD) (n=70, age < 55 yr, FEV1 < 50% predicted) were compared with older subjects with COPD (n =306, age >64 yr, FEV1 <50% predicted). MEASUREMENTS AND MAINRESULTS:
Subjects with severe, early-onset COPD were predominantly females (66%), P =0.0004. Proportionally,early-onset COPD was seen in 42% (25 of 59) of African Americans versus 14% (45 of 317) of non-Hispanic whites, P <0.0001. Other risk factors included current smoking (56 vs. 17%, P < 0.0001) and self-report of asthma (39 vs. 25%, P =0.008). Maternal smoking (70 vs. 44%, P=0.0001) and maternal COPD (23 vs.12%, P=0.03) were reported more commonly in subjects with early-onset COPD. Multivariable regression analysis found association with African American race, odds ratio (OR), 7.5 (95% confidence interval [CI], 2.324; P »=0.0007); maternal COPD, OR, 4.7 (95% CI,1.317; P=0.02); female sex, OR, 3.1 (95% CI, 1.18.7; P=0.03); and each pack-year of smoking, OR, 0.98 (95% CI, 0.961.0; P » 0.03).CONCLUSIONS:
These observations support the hypothesis that severe, early-onset COPD is prevalent in females and is influenced by maternal factors. Future genetic studies should evaluate (1) gene-by-sex interactions to address sex-specific genetic contributions and (2) gene-by-race interactions.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Negro o Afroamericano
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Enfermedad Pulmonar Obstructiva Crónica
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Madres
Tipo de estudio:
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Respir Crit Care Med
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos