Primary structure of the gamma subunit of the DHP-sensitive calcium channel from skeletal muscle.
Science
; 248(4954): 490-2, 1990 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-2158672
ABSTRACT
Affinity-purified, polyclonal antibodies to the gamma subunit of the dihydropyridine (DHP)-sensitive, voltage-dependent calcium channel have been used to isolate complementary DNAs to the rabbit skeletal muscle protein from an expression library. The deduced primary structure indicates that the gamma subunit is a 25,058-dalton protein that contains four transmembrane domains and two N-linked glycosylation sites, consistent with biochemical analyses showing that the gamma subunit is a glycosylated hydrophobic protein. Nucleic acid hybridization studies indicate that there is a 1200-nucleotide transcript in skeletal muscle but not in brain or heart. The gamma subunit may play a role in assembly, modulation, or the structure of the skeletal muscle calcium channel.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dihidropiridinas
/
Canales de Calcio
/
Músculos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1990
Tipo del documento:
Article