Spotlight on geminin.
Breast Cancer Res
; 13(3): 109, 2011 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-21639956
ABSTRACT
In the previous issue of Breast Cancer Research, Gardner and co-workers describe a novel interaction between Geminin, a protein that prevents reinitiation of DNA replication, and Topoisomerase IIα (TopoIIα), an enzyme essential for removing catenated intertwines between sister chromatids. Geminin facilitates the action of TopoIIα, thereby promoting termination of DNA replication at the same time it inhibits initiation. In this manner, Geminin ensures that cells duplicate their genome once, but only once, each time they divide. Remarkably, either depletion of Geminin or over-expression of Geminin inhibits the action of TopoIIα, thereby making Geminin an excellent target for cancer chemotherapy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mama
/
Cromosomas Humanos
/
Proteínas Serina-Treonina Quinasas
/
ADN-Topoisomerasas de Tipo II
/
Proteínas de Ciclo Celular
/
Proteínas de Unión al ADN
/
Aneuploidia
/
Antígenos de Neoplasias
Límite:
Female
/
Humans
Idioma:
En
Revista:
Breast Cancer Res
Asunto de la revista:
NEOPLASIAS
Año:
2011
Tipo del documento:
Article