Vacuolar H(+)-ATPases: intra- and intermolecular interactions.
Eur J Cell Biol
; 90(9): 688-95, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-21640428
ABSTRACT
V-ATPases in eukaryotes are heteromultimeric, H(+)-transporting proteins. They are localized in a multitude of different membranes and energize many different transport processes. Unique features of V-ATPases are, on the one hand, their ability to regulate enzymatic and ion transporting activity by the reversible dissociation of the catalytic V(1) complex from the membrane bound proton translocating V(0) complex and, on the other hand, their high sensitivity to specific macrolides such as bafilomycin and concanamycin from streptomycetes or archazolid and apicularen from myxomycetes. Both features require distinct intramolecular as well as intermolecular interactions. Here we will summarize our own results together with newer developments in both of these research areas.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ATPasas de Translocación de Protón Vacuolares
Límite:
Humans
Idioma:
En
Revista:
Eur J Cell Biol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania