Isolation of chemical constituents from the aerial parts of Verbascum thapsus and their antiangiogenic and antiproliferative activities.
Arch Pharm Res
; 34(5): 703-7, 2011 May.
Article
en En
| MEDLINE
| ID: mdl-21656353
ABSTRACT
Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de la Angiogénesis
/
Verbascum
/
Componentes Aéreos de las Plantas
/
Antineoplásicos Fitogénicos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Arch Pharm Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
China