Total synthesis of isofregenedadiol.

Kurhade, Suresh E; Sanchawala, Abbas I; Ravikumar, Velayutham; Bhuniya, Debnath; Reddy, D Srinivasa

Kurhade, Suresh E; Sanchawala, Abbas I; Ravikumar, Velayutham; Bhuniya, Debnath; Reddy, D Srinivasa.

Afiliación

Kurhade SE; Discovery Chemistry, Advinus Therapeutics Ltd., Quantum Towers, Plot No. 9, Rajiv Gandhi Infotech Park, Phase-I, Hinjewadi, Pune, 411057, India.

Org Lett ; 13(14): 3690-3, 2011 Jul 15.

Article en En | MEDLINE | ID: mdl-21699171

ABSTRACT

ABSTRACT

The first total synthesis of isofregenedadiol, a bicyclic diterpene isolated from H. Viscosum, is reported starting from a D-(-)-pantolactone chiral pool. A one-pot quadruple reaction sequence comprising an enyne ring-closing metathesis/cross-metathesis/Diels-Alder/aromatization for the construction of a target skeleton is the highlight of the present synthesis.

Asunto(s)

Diterpenos/síntesis química; Cistaceae/química; Diterpenos/química; Estructura Molecular; Resonancia Magnética Nuclear Biomolecular; Plantas Medicinales/química; Estereoisomerismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diterpenos Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2011 Tipo del documento: Article País de afiliación: India

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