Phase II study of carboplatin/ifosfamide in untreated advanced cervical cancer.
Cancer Chemother Pharmacol
; 26 Suppl: S33-5, 1990.
Article
en En
| MEDLINE
| ID: mdl-2189594
ABSTRACT
A total of 32 patients with advanced squamous-cell carcinoma of the cervix were treated with 300 mg/m2 i.v. carboplatin and 5 g/m2 ifosfamide as a 24-h i.v. infusion, both given on day 1 every 4 weeks. In all, 3 (9%) complete responses (CRs) and 19 (59%) objective responses (CR + PR) were achieved in 32 patients. Myelosuppression with leukopenia and/or thrombocytopenia of WHO grade 4 in 28% and 13% of patients, respectively, was the main toxicity. The results of our study suggest that carboplatin/ifosfamide is active as neoadjuvant treatment in advanced cervical cancer.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organoplatinos
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Neoplasias del Cuello Uterino
/
Ifosfamida
/
Antineoplásicos
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Año:
1990
Tipo del documento:
Article