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Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy.
Wada, Shogo; Kato, Yoshio; Okutsu, Mitsuharu; Miyaki, Shigeru; Suzuki, Katsuhiko; Yan, Zhen; Schiaffino, Stefano; Asahara, Hiroshi; Ushida, Takashi; Akimoto, Takayuki.
Afiliación
  • Wada S; Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan.
  • Kato Y; Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8562, Japan.
  • Okutsu M; Institute for Biomedical Engineering Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Shinjuku, Tokyo 162-0041, Japan; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 22908.
  • Miyaki S; Department of Regenerative Biology and Medicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
  • Suzuki K; Institute for Biomedical Engineering Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Shinjuku, Tokyo 162-0041, Japan; Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan.
  • Yan Z; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 22908.
  • Schiaffino S; Venetian Institute of Molecular Medicine, 35129 Padova, Italy.
  • Asahara H; Department of Regenerative Biology and Medicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.
  • Ushida T; Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan.
  • Akimoto T; Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan; Institute for Biomedical Engineering Consolidated Research Institute for Advanced Science and Medical Care, Waseda U
J Biol Chem ; 286(44): 38456-38465, 2011 Nov 04.
Article en En | MEDLINE | ID: mdl-21926429
ABSTRACT
Muscle atrophy is caused by accelerated protein degradation and occurs in many pathological states. Two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and muscle RING-finger 1 (MuRF1), are prominently induced during muscle atrophy and mediate atrophy-associated protein degradation. Blocking the expression of these two ubiquitin ligases provides protection against muscle atrophy. Here we report that miR-23a suppresses the translation of both MAFbx/atrogin-1 and MuRF1 in a 3'-UTR-dependent manner. Ectopic expression of miR-23a is sufficient to protect muscles from atrophy in vitro and in vivo. Furthermore, miR-23a transgenic mice showed resistance against glucocorticoid-induced skeletal muscle atrophy. These data suggest that suppression of multiple regulators by a single miRNA can have significant consequences in adult tissues.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Atrofia Muscular / Regulación de la Expresión Génica / Músculo Esquelético / MicroARNs Límite: Animals Idioma: En Revista: J Biol Chem Año: 2011 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Atrofia Muscular / Regulación de la Expresión Génica / Músculo Esquelético / MicroARNs Límite: Animals Idioma: En Revista: J Biol Chem Año: 2011 Tipo del documento: Article País de afiliación: Japón