Three-dimensional correlation of steric and electronic free energy relationships guides asymmetric propargylation.
Science
; 333(6051): 1875-8, 2011 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-21960632
ABSTRACT
Chemical reaction outcomes are often rationalized on the basis of independent analyses of steric and electronic effects. We applied three-dimensional free energy relationships correlating steric and electronic effects to design and optimize a ligand class for the enantioselective Nozaki-Hiyama-Kishi propargylation of ketones. The resultant mathematical model describing the steric and electronic parameter relationship is highly reliant on the synergistic interactions of these two effects.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Science
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos