Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation.
Bioorg Med Chem Lett
; 21(23): 6945-9, 2011 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-22030029
We improved the specific radioactivity of the apoptosis imaging isatin derivative (18)F-ICMT11. We then evaluated (18)F-ICMT11 in EL4 tumor-bearing mice 24h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115±0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083±0.008 SUV). This effect correlated to the observed increases in apoptotic index.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Azidas
/
Biomarcadores
/
Apoptosis
/
Radiofármacos
/
Fluorodesoxiglucosa F18
/
Indoles
/
Linfoma
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido