Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study.
Acta Neurochir (Wien)
; 154(1): 113-20; discussion 120, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22037980
ABSTRACT
OBJECTIVE:
The goal of this study was to investigate the chemokines CCL2, CXCL8, CXCL9 and CXCL10 as markers of the inflammatory responses in chronic subdural hematoma (CSDH).METHODS:
Samples of peripheral venous blood and CSDH fluid (obtained during surgery) in 76 adult patients were prospectively analyzed. Chemokine values were assessed by a Multiplex antibody bead kit.RESULTS:
We found significantly higher levels of chemokines CCL2, CXCL8, CXCL9 and CXCL10 in hematoma fluid compared with serum.CONCLUSIONS:
Chemokines are elevated in the hematoma cavity of patients with CSDH. It is likely that these signaling modulators play an important role in promoting local inflammation. Furthermore, biological activity of CCL2 and CXCL8 may promote neovascularization within the outer CSDH membrane, and a compensatory angiostatic activity of CXCL9 and CXCL10 may contribute to repairing this disorder. This phenomenon was restricted to the hematoma site, and the systemic chemokine levels might not reflect local immune responses.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Interleucina-8
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Mediadores de Inflamación
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Neovascularización Fisiológica
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Quimiocina CCL2
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Hematoma Subdural Crónico
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Quimiocina CXCL9
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Quimiocina CXCL10
Tipo de estudio:
Diagnostic_studies
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Observational_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Acta Neurochir (Wien)
Año:
2012
Tipo del documento:
Article
País de afiliación:
Noruega