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The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.
Fenner, Katherine S; Jones, Hannah M; Ullah, Mohammed; Kempshall, Sarah; Dickins, Maurice; Lai, Yurong; Morgan, Paul; Barton, Hugh A.
Afiliación
  • Fenner KS; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Sandwich, Kent, UK. katherine.fenner@astrazeneca.com
Xenobiotica ; 42(1): 28-45, 2012 Jan.
Article en En | MEDLINE | ID: mdl-22077101
ABSTRACT
Over the last two decades the impact on drug pharmacokinetics of the organic anion transporting polypeptides (OATPs OATP-1B1, 1B3 and 2B1), expressed on the sinusoidal membrane of the hepatocyte, has been increasingly recognized. OATP-mediated uptake into the hepatocyte coupled with subsequent excretion into bile via efflux proteins, such as MRP2, is often referred to as hepatobiliary excretion. OATP transporter proteins can impact some drugs in several ways including pharmacokinetic variability, pharmacodynamic response and drug-drug interactions (DDIs). The impact of transporter mediated hepatic clearance is illustrated with case examples, from the literature and also from the Pfizer portfolio. The currently available in vitro techniques to study the hepatic transporter proteins involved in the hepatobiliary clearance of drugs are reviewed herein along with recent advances in using these in vitro data to predict the human clearance of compounds recognized by hepatic uptake transporters.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema Biliar / Preparaciones Farmacéuticas / Transportadores de Anión Orgánico / Hígado Idioma: En Revista: Xenobiotica Año: 2012 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema Biliar / Preparaciones Farmacéuticas / Transportadores de Anión Orgánico / Hígado Idioma: En Revista: Xenobiotica Año: 2012 Tipo del documento: Article País de afiliación: Reino Unido