Increase in SNR for 31P MR spectroscopy by combining polarization transfer with a direct detection sequence.
Magn Reson Med
; 68(2): 353-7, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22162118
ABSTRACT
The sensitivity of (31)P MRS can be increased using higher magnetic fields, but also by using (1)H to (31)P polarization transfer techniques where the sensitivity is determined by the polarization of the proton spins and thus the signal-to-noise per unit time is unaffected by the slow T(1) relaxation properties of the (31)P spins. This implies that (31)P spins can be manipulated during the T(1) relaxation of the (1)H spins without affecting the signal-to-noise of the (1)H to (31)P polarization transferred spins. It is shown here that by combining (1)H to (31)P polarization transfer with a direct (31)P detection sequence in one repetition time, one can gain more signal-to-noise per unit of time as compared to a polarization transfer sequence alone. Proof of principle was demonstrated by phantom measurements and additionally the method was applied to the human calf muscle and to the human breast in vivo at 7 T.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Isótopos de Fósforo
/
Algoritmos
/
Procesamiento de Señales Asistido por Computador
/
Mama
/
Espectroscopía de Resonancia Magnética
/
Músculo Esquelético
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Magn Reson Med
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2012
Tipo del documento:
Article
País de afiliación:
Países Bajos