Pilot study on evaluation of any correlation between MR perfusion (Ktrans) and diffusion (apparent diffusion coefficient) parameters in brain tumors at 3 Tesla.
Cancer Imaging
; 12: 1-6, 2012 Jan 23.
Article
en En
| MEDLINE
| ID: mdl-22275724
ABSTRACT
PURPOSE:
To assess any correlation of volume transfer constant (Ktrans) with apparent diffusion coefficient (ADC) in different brain tumor types at 3 T magnetic resonance (MR) imaging. MATERIALS ANDMETHODS:
Thirteen patients with brain tumors (8 men, 5 women; mean age 54.6±17.7 years) were enrolled in this retrospective study. All patients underwent dynamic contrast-enhanced T1-weighted MR perfusion and diffusion-weighted imaging using a 3 T scanner. Ktrans was estimated by specially designed software. For each tumor, regions of interest (ROIs) were manually selected on corresponding Ktrans and ADC maps. Pearson correlation coefficients were obtained for maximum, mean and minimum values of Ktrans and ADC of all ROIs. Based on clinicopathologic results, the final diagnoses of patients were glioblastoma multiforme (3), low-grade to anaplastic gliomas (4), meningiomas (3) and metastatic tumors (3).RESULTS:
Ktrans(max) values were significantly inversely correlated with ADC(min) values (r=-0.536, P<0.001) and ADC(mean) values (r=-0.465, P<0.001). Ktrans(mean) and Ktrans(min) values were significantly inversely correlated with ADC(mean) (r=-0.228, P=0.038) and ADC(max) values (r=-0.355, P=0.001), respectively.CONCLUSION:
We found that irrespective of brain tumor type, there is an inverse correlation between ADC and Ktrans. Our findings highlight an intricate relationship between vascular permeability and the tumor microenvironment, probably modulating and/or interacting with changes such as increased cellularity, ischemic insult and varying extracellular matrix composition.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Imagen de Difusión por Resonancia Magnética
Tipo de estudio:
Observational_studies
Límite:
Aged80
Idioma:
En
Revista:
Cancer Imaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
NEOPLASIAS
Año:
2012
Tipo del documento:
Article
País de afiliación:
Hong Kong