[The Collaborative Cross, a groundbreaking tool to tackle complex traits]. / Le Collaborative Cross: un outil révolutionnaire à l'assaut des caractères complexes.
Med Sci (Paris)
; 28(1): 103-8, 2012 Jan.
Article
en Fr
| MEDLINE
| ID: mdl-22289838
ABSTRACT
Complex traits, like the susceptibility to common diseases, are controlled by numerous genomic regions which individual effect is generally weak. These observations led geneticists to develop an experimental system to dissect the genetic of complex traits in the mouse. The Collaborative Cross (CC) is a genetic reference population of over 300 inbred lines derived from eight inbred strains of three Mus musculus sub-species that captures 90% of the genetic variation known in the mouse genome. We present here the generation and the characteristics of the CC and we report the results of the first experiments with partially inbred CC lines.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Sitios de Carácter Cuantitativo
/
Estudio de Asociación del Genoma Completo
/
Ratones Endogámicos
Límite:
Animals
Idioma:
Fr
Revista:
Med Sci (Paris)
Asunto de la revista:
MEDICINA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Francia