Use of a Dacron shape-memory intravascular coil to achieve slow, progressive occlusion of the jugular vein in dogs.
Vet Surg
; 40(7): 853-60, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-22380668
ABSTRACT
OBJECTIVE:
To investigate the ability of shape memory Dacron polymer vascular coils to induce the complete, gradual occlusion of the canine jugular vein. STUDYDESIGN:
Observational pilot study. ANIMALS Nine purpose-bred dogs.METHODS:
Eighteen coils were deployed in nine dogs using fluoroscopic-guided percutaneous transvenous coil implantation. Individual coil formulations varied around a Dacron polymer base. Jugular vein diameter, percent vessel occlusion, and thrombus echogenicity were monitored at weekly intervals using ultrasonography. Affected jugular veins were harvested at 6 weeks post-implantation and histopathological analysis was performed to assess adventitial fibrosis, intimal layer thickening, and inflammation.RESULTS:
Ten coils migrated from the jugular veins to the pulmonary vasculature within 0-2 weeks following implantation. Three jugular veins achieved at least 90% occlusion at six weeks. Histopathology of these jugular veins revealed marked perivascular thickening and fibrovascular proliferation, increased infiltration of macrophages, neutrophils and lymphocytes, and abundant fibroplasia.CONCLUSIONS:
Complete, gradual occlusion of a jugular vein was achieved in three dogs. Significant vessel wall reaction and inflammation can induce gradual vessel occlusion when a Dacron coil remains implanted within the jugular vein. Dacron polymer coils could be a feasible treatment option for the gradual occlusion of congenital portosystemic shunts in dogs using minimally invasive, percutaneous transvenous implantation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Procedimientos Quirúrgicos Vasculares
/
Tereftalatos Polietilenos
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Perros
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Venas Yugulares
Límite:
Animals
Idioma:
En
Revista:
Vet Surg
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos