Influence of high-energy shock waves and cisplatin on antitumor effect in murine bladder cancer.
Urology
; 36(5): 440-4, 1990 Nov.
Article
en En
| MEDLINE
| ID: mdl-2238303
The potential application of high-energy shock waves (HESW) for control of experimental bladder cancer was investigated. Subcutaneous 3-d murine bladder cancer (MBT-2) in C3H mice were exposed to HESW alone (250 to 1,500 shocks) or in combination with cisplatin (5 to 10 mg/kg, i.p.). Although HESW alone showed no influence on tumor growth, HESW/cisplatin combination therapy suppressed tumor growth more than cisplatin alone. Subsequent studies revealed that an air-fluid interface relative to tumor location played a pivotal role for the chemosensitizing effect of HESW. HESW treatment was able to enhance the cisplatin cytotoxicity only when the tumors were placed adjacent to the air-fluid interface.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Litotricia
/
Cisplatino
Límite:
Animals
Idioma:
En
Revista:
Urology
Año:
1990
Tipo del documento:
Article