Lung volume recruitment slows pulmonary function decline in Duchenne muscular dystrophy.
Arch Phys Med Rehabil
; 93(7): 1117-22, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22421625
ABSTRACT
OBJECTIVE:
To evaluate the long-term effect on measures of forced vital capacity (FVC) before and after the introduction of regular lung volume recruitment (LVR) maneuvers (breath-stacking) in individuals with Duchenne muscular dystrophy (DMD).DESIGN:
Retrospective cohort study of pulmonary function data, including FVC, cough peak flow (CPF), maximum inspiratory pressure (MIP), and maximum expiratory pressure (MEP). Data were collected for 33 months prior to and 45 months after LVR introduction.SETTING:
Ambulatory care in a tertiary level regional rehabilitation center in Canada.PARTICIPANTS:
All individuals (N=22) with DMD (mean age ± SD, 19.6±2.4y), who were prescribed LVR and reported adherence with therapy.INTERVENTIONS:
Introduction of regular LVR (breath-stacking); 3 to 5 maximal lung inflations (maximum insufflation capacity [MIC]) using a hand-held resuscitation bag and mouthpiece, twice daily. MAIN OUTCOMEMEASURES:
Measures included the rate of decline of FVC in percent-predicted, before and after the introduction of regular LVR. Changes in maximum pressures (MIP, MEP), MIC, and cough peak flows were also measured.RESULTS:
At LVR initiation, FVC was 21.8±16.9 percent-predicted, and cough peak flows were <270L/min (144.8±106.9L/min). Annual decline of FVC was 4.7 percent-predicted a year before LVR and 0.5 percent-predicted a year after LVR initiation. The difference, 4.2 percent-predicted a year (95% confidence interval, 3.5-4.9; P<.000), represents an 89% improvement in the annual rate of FVC decline.CONCLUSIONS:
The rate of FVC decline in DMD patients improves dramatically with initiation of regular LVR.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Insuficiencia Respiratoria
/
Capacidad Vital
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Distrofia Muscular de Duchenne
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Mediciones del Volumen Pulmonar
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arch Phys Med Rehabil
Año:
2012
Tipo del documento:
Article
País de afiliación:
Canadá